The research aims at the characterization and understanding of the molecular mechanisms that can explain the response of cellular organelles and prokaryotic systems involved in energy transduction, to different conditions of stress.
The research activities concern expression, structure and assembly of membrane energy transducing systems of both prokaryotes and eukaryotes. Structural and functional relationships of OXPHOS complexes.
It is involved in the identification and in the functional and structural characterization of mitochondrial membrane transporters belonging to the family SLC25 known as "mitochondrial carrier family (MCF)".
Objective of the research is the study of signaling pathways and mitochondrial metabolism in different models of neurodegenerative/neurodevelopmental diseases and in cancer.
Despite the great advances in biological research in recent years, we still have a very limited knowledge of the wide variety of species that inhabit the earth in its various environments, and their dynamics in relation to different ecosystems, environmental pollution and climate changes.
Atanasov AG, Zotchev SB, Dirsch VM; International Natural Product Sciences Taskforce*, Supuran CT. *International Natural Product Sciences Taskforce: Ilkay Erdogan Orhan, Maciej Banach, Judith M. Rollinger, Davide Barreca, Wolfram Weckwerth, Rudolf Bauer, Edward A. Bayer, Muhammed Majeed, Anupam Bishayee, Valery Bochkov, Günther K. Bonn, Nady Braidy, Franz Bucar, Alejandro Cifuentes, Grazia D’Onofrio, Michael Bodkin, Marc … Continue reading Natural products in drug discovery: advances and opportunities. 2021. Nat Rev Drug Discov. Mar;20(3):200-216. Review
REDIdb is a freely available database that focuses on the organellar RNA editing process in plants organellar genomes and annotates each editing modification in its biological context. Currently the database is at its third version and contains 11,897 editing events spread over a total of 198 organisms and 929 different nucleotide sequences. REDIdb can be … Continue reading Database: REDIdb
SCIENTIFIC-RESEARCH PROJECT n° 01-781/2 New methods for risk stratification for progression of cancer and Alzheimer’s disease in patients in Montenegro (DEMONSTRATE) https://www.demonstrate.ucg.ac.me/